A comprehensive guide to the CSF proteome

CSF-PR 2.0: an interactive literature guide to quantitative cerebrospinal fluid mass spectrometry data from neurodegenerative disorders. Guldbrandsen et al., Molecular & Cellular Proteomics 2017 (in press)

The rapidly growing number of biomedical studies supported by mass spectrometry based quantitative proteomics data has made it increasingly difficult to obtain an overview of the current status of the field. A better way of organizing the information from these studies and making it available to the research community is therefore called for. In the presented work, we investigated scientific publications describing the analysis of the cerebrospinal fluid proteome in relation to multiple sclerosis, Parkinson’s disease and Alzheimer’s disease. Based on a detailed set of filtering criteria we extracted 85 datasets containing quantitative information for close to 2000 proteins. This information is now available in CSF-PR 2.0 (http://probe.uib.no/csf-pr-2.0), including novel approaches for filtering, visualizing and comparing quantitative proteomics information in an interactive and user-friendly environment. CSF-PR 2.0 should thus be an invaluable resource for anyone interested in quantitative proteomics on cerebrospinal fluid.