We have developed a mathematical model that describes the time evolution of hormones along the hypothalamic-pituitary-gonadal (HPG) axis and the growth of ovarian follicles throughout consecutive human menstrual cycles.
We have applied this model to study the pharmacokinetics and pharmacodynamics of GnRH analogues as well as ovarian hyperstimulation protocols in reproductive endocrinology.
We are currently in the process of coupling the HPG axis model with other hormonal axes to study, e.g., the influence of hormonal contraceptives on the stress response in women.
Mathematical modelling of follicular growth and ovarian stimulation. Current Opinion in Endocrine and Metabolic Research 2022
Hormonal regulation of ovarian follicle growth in humans: Model-based exploration of cycle variability and parameter sensitivities. Journal of Theoretical Biology 2022
Mathematical Modeling and Simulation Provides Evidence for New Strategies of Ovarian Stimulation. Frontiers in Endocrinology 2021